Work Package 1

Dissecting the neurobiology in the course of affective disorders – the Marburg-Münster affective disorders cohort study (MACS)

Prof. Dr. Dr. Udo Dannlowki1, Prof. Dr. Axel Krug², Prof. Dr. Igor Nenadić², Prof. Dr. Tilo Kircher2

1University of Münster, Department of Psychiatry and Psychotherapy, Münster
²University of Marburg, Department of Psychiatry and Psychotherapy

The present project (Work Package 1) serves as the human backbone study of FOR2107. During the 1st funding period, a large cohort was successfully established, the Marburg/Münster Affective Disorders Cohort Study (MACS). The sample (total N=2500) includes 1. n=1000 patients suffering from affective disorders (projected n=700 MDD and n=300 BD), extended by subsamples of schizophrenia and schizoaffective disorder patients, 2. n=500 healthy risk subjects either carrying genetic (1st degree relative affected), environmental (childhood maltreatment) or both risks factors, and 3. n=1000 healthy subjects without known risk factors. All participants were deeply phenotyped by multimodal MR-imaging, clinical assessment, neuropsychology, and biomaterial analyses. The imaging battery includes three functional paradigms, two probing neurobiological responses during emotion processing (particularly amygdala function), and an episodic memory paradigm eliciting robust hippocampus activation. Brain structure is investigated by morphometric methods on structural T1-images, and a DTI sequence was employed for investigating white matter structure. WP1 acquires and provides a biomaterial collection for the human parts in the molecular Work Packages (Work Packages 3-5), which will be stored, processed and distributed within a central biobanking project (Central Project 1). (Epi-)Genetic- and transcriptome analyses on Work Package 1 subjects, including genome-wide association data (GWAS) will be conducted in Work Package 5. In Work Package 4, immune mechanisms will be investigated and in Work Package 3, analyses regarding miRNA regulation are conducted. Objective of the 2nd funding period is the 2-year follow-up of the entire cohort, which has already started, employing the entire phenotyping battery, including imaging and biomaterial acquisition. The project will build up a unique, large imaging and biomaterial database which will serve to validate hypotheses regarding gene, environment, and gene-environment interactions on brain structure and function in the longitudinal course of illness. Particularly the follow-up data of the 2nd funding period enables analyses regarding prediction of illness course and clustering of novel, biologically informed subgroups (biotypes). Data analyses are conducted in close collaboration with a statistical and methodological work package (Work Package 6), assuring MRI reliability in the course of data collection and statistical support for biotype data reduction procedures, GWAS on brain imaging data, and the implementation of novel, machine learning based approaches. Together with the nested Work Packages of this FOR, Work Package 1 will help to pave the way for a neurobiologically validated conception of the etiology and the longitudinal course of affective disorders.

Project Manager

Prof. Dr. Dr. Udo Dannlowski

Prof. Dr. Dr. Udo Dannlowski

Prof. Dr. Axel Krug

Prof. Dr. Axel Krug

Prof. Dr. Igor Nenadić

Prof. Dr. Igor Nenadić

Prof. Dr. Tilo Kircher

Prof. Dr. Tilo Kircher

Employees

Dr. Bruno Dietsche, Postdoctoral Fellow (Marburg)

Dr. Bruno Dietsche, Postdoctoral Fellow (Marburg)

Dr. Dominik Grotegerd, Postdoctoral Fellow (Münster)

Dr. Dominik Grotegerd, Postdoctoral Fellow (Münster)

Dr. Ronny Redlich, Postdoctoral Fellow (Münster)

Dr. Ronny Redlich, Postdoctoral Fellow (Münster)

Henrike Bröhl, M.Sc. (Marburg)

Henrike Bröhl, M.Sc. (Marburg)

Christian Bürger, M.Sc. (Münster)

Christian Bürger, M.Sc. (Münster)

Katharina Dohm, M.Sc. (Münster)

Katharina Dohm, M.Sc. (Münster)

Verena Enneking, M.Sc. (Münster)

Verena Enneking, M.Sc. (Münster)

Katharina Förster, M.Sc. (Münster)

Katharina Förster, M.Sc. (Münster)

Susanne Leonie Meinert, M.Sc. (Münster)

Susanne Leonie Meinert, M.Sc. (Münster)

Torsten Sauder, M.Sc. (Marburg)

Torsten Sauder, M.Sc. (Marburg)

Simon Schmitt, M.Sc. (Marburg)

Simon Schmitt, M.Sc. (Marburg)

Dario Zaremba, M.Sc. (Münster)

Dario Zaremba, M.Sc. (Münster)

Dilara Yüksel, M.Sc. (Marburg)

Dilara Yüksel, M.Sc. (Marburg)

Sabine Fischer, TA (Marburg)

Sabine Fischer, TA (Marburg)

Kordula Vorspohl, TA (Münster)

Kordula Vorspohl, TA (Münster)

Mechthild Wallnig, MTRA (Marburg)

Mechthild Wallnig, MTRA (Marburg)

Rita Werner, MTRA (Marburg)

Rita Werner, MTRA (Marburg)

Leni Aldermann, cand. med. (Münster)

Leni Aldermann, cand. med. (Münster)

Silvia Blaschke, cand. med. (Marburg)

Silvia Blaschke, cand. med. (Marburg)

Lea Grill, cand. med. (Marburg)

Lea Grill, cand. med. (Marburg)

Sarah Bockholt, cand. med. (Münster)

Sarah Bockholt, cand. med. (Münster)

Elena Fischer, cand. med. (Marburg)

Elena Fischer, cand. med. (Marburg)

Alexander Leonard Frisch, cand. med. (Marburg)

Alexander Leonard Frisch, cand. med. (Marburg)

Lena Fröhlich, cand. med. (Marburg)

Lena Fröhlich, cand. med. (Marburg)

Christian Fromm, cand. med. (Marburg)

Christian Fromm, cand. med. (Marburg)

Theresa Hahn, cand. med. (Münster)

Theresa Hahn, cand. med. (Münster)

Eleni Holstein, cand. med. (Marburg)

Eleni Holstein, cand. med. (Marburg)

Amelie König, cand. med. (Münster)

Amelie König, cand. med. (Münster)

Pia Krüssel, cand. med. (Münster)

Pia Krüssel, cand. med. (Münster)

Marcia Lippitz, cand. med. (Münster)

Marcia Lippitz, cand. med. (Münster)

Theresa Nick, cand. med. (Münster)

Theresa Nick, cand. med. (Münster)

Nico Nowak, cand. med. (Münster)

Nico Nowak, cand. med. (Münster)

Leonie Plümpe, cand. med. (Münster)

Leonie Plümpe, cand. med. (Münster)

Emily Schlaghecken, cand. med. (Münster)

Emily Schlaghecken, cand. med. (Münster)

Tilmann Schlegel, cand. med. (Marburg)

Tilmann Schlegel, cand. med. (Marburg)

Tim Schneider, cand. med. (Marburg)

Tim Schneider, cand. med. (Marburg)

Robin Schnelle, cand. med. (Münster)

Robin Schnelle, cand. med. (Münster)

Nina Schröder, cand. med. (Münster)

Nina Schröder, cand. med. (Münster)

Felix Stahl, cand. med. (Münster)

Felix Stahl, cand. med. (Münster)

Anna Milena Straßburg, cand. med. (Münster)

Anna Milena Straßburg, cand. med. (Münster)

Robert Strojny, cand. med. (Münster)

Robert Strojny, cand. med. (Münster)

Lena Winters, cand. med. (Münster)

Lena Winters, cand. med. (Münster)

Helena Block, Student Assistant (Marburg)

Helena Block, Student Assistant (Marburg)

Dorothee Micheln, Student Assistant (Münster)

Dorothee Micheln, Student Assistant (Münster)

Julian Maretzek, Student Assistant (Münster)

Julian Maretzek, Student Assistant (Münster)

Pascal Schipper, Student Assistant (Münster)

Pascal Schipper, Student Assistant (Münster)